Erfolge mittels Rudererergometer und anaerobe leistungsmöglichkeit bei den Ruderern-studenten

The aim of the study presented was to assess the relationships between the 6-minute "all-out" rowing ergometer test with physical performance indices in college rowers. Ten male rowers (21.60+4.20 yrs; 186,90+5.64 cm; 84.10+6.59 kg; %body fat: 9.62+2.81%) performed a 6-minute "all-out" rowing ergometer test on a rowing ergometer (Concept II, USA) at the first measurement session. In addition, a graded exercise test at the intensities of 150, 200 and 250 W (6-minutes each) and a maximal 5x1 minute interval test were performed at separate measurement sessions. The heart rate (HR) was recorded at the end of each load during a graded exercise test. The individual physical working capacity (PWC) of the rowers was calculated at the maximum of HR recorded during a 6-minute "all-out" test. Blood samples for lactate (LA) determination were obtained from the fingertip before and immediately after each bout of exercise. The anaerobic threshold (AT) indices were determined by interpolation from the relationships between the LA concentration and the respective variable at a LA concentration of 4.0 mmol/l. The LA concentration in the blood was also determined before, immediately after and after 3 minutes and 5 minutes of recovery of the maximal 5 x 1 minute interval test. Significant correlations (p<0.05) were observed between the AT (W) and power (r=0.56) and the covered distance (r=0.55) of a 6-minute "all-out" test. In addition, the power and distance covered of the 6-minute "all-out" test were significantly related to the covered distance and power of all five trials of the maximum interval test (r=0.64-0.77). The stepwise multiple interval test indicated that the power of a 6-minute "all-out" test was explained by the mean power of a maximal 5 x 1 minute interval test at 82.75% (R2). In conclusion, the results of our study suggest that our proposed interval test has a high diagnostic value in the assessment of the anaerobic work capacity of rowers.Das Ziel dieser Untersuchung war, die Zusammenhange zwischen 6-Minuten Leistungstest mittels eines Rudererergometers und Indexen der körperlichen Leistungsmöglichkeit von Ruderern-Studenten zu erstellen. Zehn männliche Ruderer (21.60+/-4.20 Jahre; 186,90+/-5,64cm; 84,10+/-6,59kg; 9,62+/-2,81% Fettgewebe) wurden dem 6-Minuten Leistungstest am Rudererergometer (Concept II, USA) in der ersten Messung unterzogen. Zusätzlich wurden der progressive Belastungstest mit den Werten 150, 200 und 250 W (je 6 Minuten) und der Intervall-Leistungstest in der Zeitspanne von 5x1 Minute in abgesonderten Messungen durchgeführt. Die Herzfrequenz (Heart Rate - HR) wurde in der Endphase jeder Belastung des Stufentestes gemessen. Persönliche körperliche Arbeitsleistung (PWC - engl. physical working capacity) der Ruderer wurde nach maximal gemessener Herzfrequenz in der Zeitspanne des 6-Minuten Leistungtestes errechnet. Aus der Fingerkuppe wurden vor und nach jeder Leistung die Blutproben zur Feststellung des Milchsäurespiegels (LA) entnommen. Die Indexe der anaeroben Schwelle (anaerobic threshold - AT) wurden nach der vorgenommenen Interpolation der Wechselbeziehung zwischen dem LA-Spiegel und der entsprechenden Variable mit der Konzentration von 4,0 mmol/ festgestellt. Der LA-Spiegel wurde im Blut vorher, anschließend, 3 wie auch 5 Minuten nach dem Intervall-Leistungstest 5x1 gemessen. Es wurde eine bedeutende Wechselbeziehung (p<0,05) zwischen der anaeroben Schwelle (W) und dem Kraftaufwand (r=0,56) einerseits und der zurückgelegten Entfernung (r=0,55) in den Zeitspannen des Leistungtestes festgestellt. Der Kraftaufwand und die zurückgelegten Entfernung im Laufe des Leistungtestes hingen auch bedeutend von der zurückgelegten Entfernung und dem Kraftaufwandin allen fünf Zeitspannen des Intervall- Leistungtestes (r=0,64-0,77) ab, Der wicderholende Intervall-Test mit progressiver Belastung ‘beweist, dass sich der 82,75% (R2) Kraftaufwand, gemessen in 6-Minuten Leistungtest, über arithmetisches Mittel vom Kraftaufwand, gemessen im Leistungtest mit Intervallen von 5x1 Minute erklären lasst. Wir schlussfolgern, dass die Ergebnisse unserer Untersuchung darauf hinweisen, wie hoch der diagnostische Wert des vorgeschlagenen Intervall-Leistungtests bei der Einschätzung von Arbeitsleistung der Ruderer ist

Hvorfor falder studerende fra? En opsummering af EVA’s analyser af frafald på de videregående uddannelser

Frafald er et stædigt problem, som optager mange i uddannelsessektoren. Og med god grund. Omkring hver tredje studerende, der optages på en videregående uddannelse, ender med at falde fra, og frafald er forbundet med betydelige omkostninger for de studerende, som beslutter sig for at afbryde uddannelsen, for uddannelsesinstitutionerne og for samfundet. Det er næppe hverken ønskeligt eller muligt at nedbringe frafaldet til nul. Uanset hvor god vejledning og information de unge får, vil nogle unge opleve at have truffet det forkerte studievalg, og i disse tilfælde vil det være i alles interesse, at uddannelsesforløbene afbrydes. Derudover er en stor del af frafaldet i realiteten studieskift: Kun en ud af otte (12 %) af de optagne falder fra uden at starte på en anden videregående uddannelse efterfølgende (EVA, 2021a). Det har naturligvis stor betydning for de samlede omkostninger forbundet med frafald, som i et lidt længere perspektiv i høj grad hænger sammen med de unges karriere på arbejdsmarkedet. Her har en tidligere analyse foretaget af EVA vist, at unge, der ikke færdiggør en videregående uddannelse, har markant højere risiko for at modtage offentlig forsørgelse sammenlignet med unge, som gennemfører. Det gælder i øvrigt også for udsatte unge (EVA, 2019f ). Alligevel giver det god mening at bestræbe sig på at nedbringe frafaldet, og her er der meget, man kan interessere sig for. Fx er det oplagt, at de studerendes studievalg og optagelsesprocessen har betydning. Det er også oplagt at forhold på uddannelsen som fremmer engagement, motivation og læringsudbytte har betydning for de studerendes frafaldssandsynlighed. Endelig er der en række aspekter ved fx de studerendes baggrund, som uddannelsen ikke umiddelbart kan påvirke, men hvor det alligevel kan være værdifuldt at kende til de forhold og karakteristika, der hænger sammen med en højere frafaldsrisiko. På EVA har vi siden 2016 gennemført en række undersøgelser med henblik på at kunne belyse faktorer, der hænger sammen med frafald på de videregående uddannelser. Vi vil i denne artikel kort introducere EVA’s tilgang til feltet og dernæst opsummere resultaterne fra de analyser af frafald, som EVA har gennemført gennem de senere år.

SARS-CoV-2 Production in a Scalable High Cell Density Bioreactor

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has demonstrated the value of pursuing different vaccine strategies. Vaccines based on whole viruses, a widely used vaccine technology, depend on efficient virus production. This study aimed to establish SARS-CoV-2 production in the scalable packed-bed CelCradle(TM) 500-AP bioreactor. CelCradle(TM) 500-AP bottles with 0.5 L working volume and 5.5 g BioNOC™ II carriers were seeded with 1.5 × 10(8) Vero (WHO) cells, approved for vaccine production, in animal component-free medium and infected at a multiplicity of infection of 0.006 at a total cell number of 2.2–2.5 × 10(9) cells/bottle seven days post cell seeding. Among several tested conditions, two harvests per day and a virus production temperature of 33 °C resulted in the highest virus yield with a peak SARS-CoV-2 infectivity titer of 7.3 log(10) 50% tissue culture infectious dose (TCID(50))/mL at 72 h post-infection. Six harvests had titers of ≥6.5 log(10) TCID(50)/mL, and a total of 10.5 log(10) TCID(50) were produced in ~5 L. While trypsin was reported to enhance virus spread in cell culture, addition of 0.5% recombinant trypsin after infection did not improve virus yields. Overall, we demonstrated successful animal component-free production of SARS-CoV-2 in well-characterized Vero (WHO) cells in a scalable packed-bed bioreactor

A rare case of repeated anastomotic recurrence due to tumor implantation after curative surgery for sigmoid colon cancer

<p>Abstract</p> <p>Background</p> <p>Anastomotic recurrence is often experienced at colocolic or colorectal anastomoses. Tumor cell implantation has been reported as the mechanism of anastomotic recurrence. However, anastomotic recurrence occurring repeatedly after curative surgery is rare. We herein report a rare case of repeated anastomotic recurrence after curative surgery for sigmoid colon cancer.</p> <p>Case presentation</p> <p>A 51-year-old man underwent radical surgery for sigmoid colon cancer. However, anastomotic recurrence developed three times during three years and six months after the initial operation in spite of irrigation with 5% povidone-iodine before anastomosis. The serum carcinoembryonic antigen (CEA) level had been within normal limits after sigmoidectomy. Finally, the patient underwent abdominoperineal resection. The clinico-pathological findings revealed that possible tumor cell implantation caused these anastomotic recurrences. The patients survived without recurrence during the follow-up period of seven years and nine months.</p> <p>Conclusion</p> <p>We experienced a rare case of repeated anastomotic recurrence due to possible tumor implantation after curative surgery for sigmoid colon cancer; however the prognosis was ultimately very good. CEA monitoring was insensitive for detection of anastomotic recurrence in this case.</p

An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics

For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic annotation data along with multi-platform molecular profiles of more than 11,000 human tumors across 33 different cancer types. TCGA clinical data contain key features representing the democratized nature of the data collection process. To ensure proper use of this large clinical dataset associated with genomic features, we developed a standardized dataset named the TCGA Pan-Cancer Clinical Data Resource (TCGA-CDR), which includes four major clinical outcome endpoints. In addition to detailing major challenges and statistical limitations encountered during the effort of integrating the acquired clinical data, we present a summary that includes endpoint usage recommendations for each cancer type. These TCGA-CDR findings appear to be consistent with cancer genomics studies independent of the TCGA effort and provide opportunities for investigating cancer biology using clinical correlates at an unprecedented scale. Analysis of clinicopathologic annotations for over 11,000 cancer patients in the TCGA program leads to the generation of TCGA Clinical Data Resource, which provides recommendations of clinical outcome endpoint usage for 33 cancer types

Variability and connectivity of plaice populations from the Eastern North Sea to the Western Baltic Sea, and implications for assessment and management

An essential prerequisite of sustainable fisheries is the match between biologically relevant processes and management action. Various populations may however co-occur on fishing grounds, although they might not belong to the same stock, leading to poor performance of stock assessment and management. Plaice in Kattegat and Skagerrak have traditionally been considered as one stock unit. Current understanding indicates that several plaice components may exist in the transition area between the North Sea and the Baltic Sea. A comprehensive review of all available biological knowledge on plaice in this area is performed, including published and unpublished literature together with the analyses of commercial and survey data and historical tagging data. The results suggest that plaice in Skagerrak is closely associated with plaice in the North Sea, although local populations are present in the area. Plaice in Kattegat, the Belts Sea and the Sound can be considered a stock unit, as is plaice in the Baltic Sea. The analyses revealed great heterogeneity in the dynamics and productivity of the various local components, and suggested for specific action to maintain biodiversity

Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation

Age is a non-modifiable risk factor for the inflammation that underlies age-associated diseases; thus, anti-inflammaging drugs hold promise for increasing health span. Cytokine profiling and bioinformatic analyses showed that Th17 cytokine production differentiates CD4+ T cells from lean, normoglycemic older and younger subjects, and mimics a diabetes-associated Th17 profile. T cells from older compared to younger subjects also had defects in autophagy and mitochondrial bioenergetics that associate with redox imbalance. Metformin ameliorated the Th17 inflammaging profile by increasing autophagy and improving mitochondrial bioenergetics. By contrast, autophagy-targeting siRNA disrupted redox balance in T cells from young subjects and activated the Th17 profile by activating the Th17 master regulator, STAT3, which in turn bound IL-17A and F promoters. Mitophagy-targeting siRNA failed to activate the Th17 profile. We conclude that metformin improves autophagy and mitochondrial function largely in parallel to ameliorate a newly defined inflammaging profile that echoes inflammation in diabetes

A systematic review of musculoskeletal disorders among school teachers

<p>Abstract</p> <p>Background</p> <p>Musculoskeletal disorders (MSD) represent one of the most common and most expensive occupational health problems in both developed and developing countries. School teachers represent an occupational group among which there appears to be a high prevalence of MSD. Given that causes of MSD have been described as multi-factorial and prevalence rates vary between body sites and location of study, the objective of this systematic review was to investigate the prevalence and risk factors for MSD among teaching staff.</p> <p>Methods</p> <p>The study involved an extensive search of MEDLINE and EMBASE databases in 2011. All studies which reported on the prevalence and/or risk factors for MSD in the teaching profession were initially selected for inclusion. Reference lists of articles identified in the original search were then examined for additional publications. Of the 80 articles initially located, a final group of 33 met the inclusion criteria and were examined in detail.</p> <p>Results</p> <p>This review suggests that the prevalence of self-reported MSD among school teachers ranges between 39% and 95%. The most prevalent body sites appear to be the back, neck and upper limbs. Nursery school teachers appear to be more likely to report suffering from low back pain. Factors such as gender, age, length of employment and awkward posture have been associated with higher MSD prevalence rates.</p> <p>Conclusion</p> <p>Overall, this study suggests that school teachers are at a high risk of MSD. Further research, preferably longitudinal, is required to more thoroughly investigate the issue of MSD among teachers, with a greater emphasis on the possible wider use of ergonomic principles. This would represent a major step forward in the prevention of MSD among teachers, especially if easy to implement control measures could be recommended.</p

Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context

Long noncoding RNAs (lncRNAs) are commonly dys-regulated in tumors, but only a handful are known toplay pathophysiological roles in cancer. We inferredlncRNAs that dysregulate cancer pathways, onco-genes, and tumor suppressors (cancer genes) bymodeling their effects on the activity of transcriptionfactors, RNA-binding proteins, and microRNAs in5,185 TCGA tumors and 1,019 ENCODE assays.Our predictions included hundreds of candidateonco- and tumor-suppressor lncRNAs (cancerlncRNAs) whose somatic alterations account for thedysregulation of dozens of cancer genes and path-ways in each of 14 tumor contexts. To demonstrateproof of concept, we showed that perturbations tar-geting OIP5-AS1 (an inferred tumor suppressor) andTUG1 and WT1-AS (inferred onco-lncRNAs) dysre-gulated cancer genes and altered proliferation ofbreast and gynecologic cancer cells. Our analysis in-dicates that, although most lncRNAs are dysregu-lated in a tumor-specific manner, some, includingOIP5-AS1, TUG1, NEAT1, MEG3, and TSIX, synergis-tically dysregulate cancer pathways in multiple tumorcontexts